Description: Metabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes

Diabetes remission type 1


    Men and women between the ages of 30 and 80 years inclusive 2.

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    Negative for anti-glutamic acid decarboxylase anti-GAD antibodies 4. A1c at screening between 5.

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    Negative pregnancy test at recruitment for all women with childbearing potential Exclusion Criteria: 1. Current anti-diabetic treatment with insulin, diabetes remission type 1, thiazolidinedione, alpha-glucosidase inhibitor, glucagon-like peptide-1 GLP-1 agonist or dipeptidyl peptidase-4 inhibitor 2.

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    Type 1 diabetes or secondary forms of diabetes 3. History of hypoglycemia unawareness or severe hypoglycemia requiring assistance 4.

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    Hypersensitivity to insulin, metformin or the formulations of these products 6. History of congestive heart failure 9.

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    Unwillingness to administer insulin therapy or perform capillary blood glucose monitoring at least 4 times per day while receiving IIT Pregnancy or unwillingness to use reliable contraception. Women should not be planning pregnancy for the duration of the study or the first 3 months after the study. Reliable contraception includes birth control pill, intra-uterine device, abstinence, tubal ligation, partner vasectomy, or condoms with spermicide.

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    Non-adherence to the induction phase or any factor likely to limit adherence to the study protocol, in the opinion of the investigator Nem:.